The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue

Tuberculosis remains a leading cause of death worldwide, despite the availability of effective chemotherapy and a vaccine. Bacillus Calmette–Guérin (BCG), the tuberculosis vaccine, is an attenuated mutant of Mycobacterium bovis that was isolated after serial subcultures, yet the functional basis for...

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Detalles Bibliográficos
Main Authors: Hsu, Tsungda, Hingley-Wilson, Suzanne M., Chen, Bing, Chen, Mei, Dai, Annie Z., Morin, Paul M., Marks, Carolyn B., Padiyar, Jeevan, Goulding, Celia, Gingery, Mari, Eisenberg, David, Russell, Robert G., Derrick, Steven C., Collins, Frank M., Morris, Sheldon L., King, C. Harold, Jacobs, William R.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC218773/
https://ncbi.nlm.nih.gov/pubmed/14557547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1635213100
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