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Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme
The target antigen of anti-neutrophil cytoplasm antibodies (ACPA; also known as ANCA) was isolated by affinity chromatography from supernatants of human neutrophils, stimulated with phorbol ester to induce degranulation. Sequence analysis of the antigen revealed 17 NH2- terminal amino acids (IVGGHEA...
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| Format: | Artigo |
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| Language: | Inglês |
| Published: |
The Rockefeller University Press
1990
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2187669/ https://ncbi.nlm.nih.gov/pubmed/1688612 |
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