Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway

Smooth muscle cell proliferation around small pulmonary vessels is essential to the pathogenesis of pulmonary hypertension. Here we describe a molecular mechanism and animal model for this vascular pathology. Rodents engineered to express angiopoietin 1 (Ang-1) constitutively in the lung develop sev...

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Bibliografiske detaljer
Main Authors: Sullivan, Christopher C., Du, Lingling, Chu, Danny, Cho, Augustine J., Kido, Masakuni, Wolf, Paul L., Jamieson, Stuart W., Thistlethwaite, Patricia A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC218758/
https://ncbi.nlm.nih.gov/pubmed/14512515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1933740100
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