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Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway
Smooth muscle cell proliferation around small pulmonary vessels is essential to the pathogenesis of pulmonary hypertension. Here we describe a molecular mechanism and animal model for this vascular pathology. Rodents engineered to express angiopoietin 1 (Ang-1) constitutively in the lung develop sev...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC218758/ https://ncbi.nlm.nih.gov/pubmed/14512515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1933740100 |
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