Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway

To study the physiological and molecular mechanisms of age-related memory loss, we assessed spatial memory in C57BL/B6 mice from different age cohorts and then measured in vitro the late phase of hippocampal long-term potentiation (L-LTP). Most young mice acquired the spatial task, whereas only a mi...

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Bibliographic Details
Main Authors: Bach, Mary Elizabeth, Barad, Mark, Son, Hyeon, Zhuo, Min, Lu, Yun-Fei, Shih, Robert, Mansuy, Isabelle, Hawkins, Robert D., Kandel, Eric R.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC21855/
https://ncbi.nlm.nih.gov/pubmed/10220457
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