Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection
Interactions between αβ T cell receptors and peptides bound to molecules encoded by the MHC genes underly T cell activation. More than 1% of T cells are activated by foreign (allogenic) MHC molecules, a phenomenon called alloreactivity. Reconciling the high frequency of alloreactivity with the fact...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1999
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21832/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10220434/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.9.5153 |
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