Conditional Immortalization of Human B Cells by CD40 Ligation

It is generally assumed that human differentiated cells have a limited life-span and proliferation capacity in vivo, and that genetic modifications are a prerequisite for their immortalization in vitro. Here we readdress this issue, studying the long-term proliferation potential of human B cells. It...

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Bibliographic Details
Main Authors: Wiesner, Martina, Zentz, Caroline, Mayr, Christine, Wimmer, Rainer, Hammerschmidt, Wolfgang, Zeidler, Reinhard, Moosmann, Andreas
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2180193/
https://ncbi.nlm.nih.gov/pubmed/18213373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001464
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