Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles.

1. 7-Nitro indazole (7-NI) produces potent inhibition of rat cerebellar nitric oxide synthase (NOS) with an IC50 of 0.9 +/- 0.1 microM (n = 6). NOS activity is dependent on the presence of both exogenous CaCl2 and NADPH. The inhibitory potency of 7-NI remained unaltered in the presence of different...

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Main Authors: Babbedge, R. C., Bland-Ward, P. A., Hart, S. L., Moore, P. K.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1993
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175991/
https://ncbi.nlm.nih.gov/pubmed/7693279
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