Nasal administration of an ACTH(4-9) peptide analogue with dimethyl-beta-cyclodextrin as an absorption enhancer: pharmacokinetics and dynamics.

1. The systemic absorption and the neurotrophic effect of the metabolically stabilized ACTH (4-9) analogue, Org2766, were investigated following intranasal (i.n.) administration. 2. Without additives the nasal bioavailability of the peptide was in the order of 15 and 10% in rats and rabbits, respect...

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Autors principals: Schipper, N. G., Verhoef, J. C., De Lannoy, L. M., Romeijn, S. G., Brakkee, J. H., Wiegant, V. M., Gispen, W. H., Merkus, F. W.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1993
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175873/
https://ncbi.nlm.nih.gov/pubmed/8306072
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