Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580.

1. Release of substance P in the dorsal horn is considered a primary event in the perception of pain. The profile of racemic RP67580, a non-peptide antagonist at the NK1 (substance P) receptor, was examined in a range of antinociception tests on rodents. 2. At doses up to 30 mg kg-1, s.c. racemic RP...

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Main Authors: Rupniak, N. M., Boyce, S., Williams, A. R., Cook, G., Longmore, J., Seabrook, G. R., Caeser, M., Iversen, S. D., Hill, R. G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175864/
https://ncbi.nlm.nih.gov/pubmed/8306108
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