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Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length
Poly(ADP-ribose) (PAR) is synthesized by poly(ADP-ribose) polymerases in response to genotoxic stress and interacts non-covalently with DNA damage checkpoint and repair proteins. Here, we present a variety of techniques to analyze this interaction in terms of selectivity and affinity. In vitro synth...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2175335/ https://ncbi.nlm.nih.gov/pubmed/17991682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm944 |
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