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Extent to which hairpin opening by the Artemis:DNA-PKcs complex can contribute to junctional diversity in V(D)J recombination

V(D)J recombination events are initiated by cleavage at gene segments by the RAG1:RAG2 complex, which results in hairpin formation at the coding ends. The hairpins are opened by the Artemis:DNA-PKcs complex, and then joined via the nonhomologous DNA end joining (NHEJ) process. Here we examine the op...

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מידע ביבליוגרפי
Main Authors: Lu, Haihui, Schwarz, Klaus, Lieber, Michael R.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175297/
https://ncbi.nlm.nih.gov/pubmed/17932067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm823
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