Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis

To test the role of ER luminal environment in apoptosis, we generated HeLa cell lines inducible with respect to calreticulin and calnexin and investigated their sensitivity to drug-dependent apoptosis. Overexpression of calreticulin, an ER luminal protein, resulted in an increased sensitivity of the...

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Autori principali: Nakamura, Kimitoshi, Bossy-Wetzel, Ella, Burns, Kimberly, Fadel, Marc P., Lozyk, Mira, Goping, Ing Swie, Opas, Michal, Bleackley, R. Chris, Green, Douglas R., Michalak, Marek
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2000
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175288/
https://ncbi.nlm.nih.gov/pubmed/10952999
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