Profilin Enhances Cdc42-Induced Nucleation of Actin Polymerization

We find that profilin contributes in several ways to Cdc42-induced nucleation of actin filaments in high speed supernatant of lysed neutrophils. Depletion of profilin inhibited Cdc42-induced nucleation; re-addition of profilin restored much of the activity. Mutant profilins with a decreased affinity...

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Autores principales: Yang, Changsong, Huang, Minzhou, DeBiasio, John, Pring, Martin, Joyce, Michael, Miki, Hiroaki, Takenawa, Tadaomi, Zigmond, Sally H.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2000
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175244/
https://ncbi.nlm.nih.gov/pubmed/10973991
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