The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse

The varicella-zoster virus (VZV) genes ORF47 and ORF66 are predicted to encode serine/threonine protein kinases, which are homologs of herpes simplex virus 1 (HSV-1) UL13, and US3. When mutants were constructed by inserting stop codons into ORF47 and ORF66, the recombinants ROka47S and ROka66S, as w...

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Bibliographic Details
Main Authors: Moffat, Jennifer F., Zerboni, Leigh, Sommer, Marvin H., Heineman, Thomas C., Cohen, Jeffrey I., Kaneshima, Hideto, Arvin, Ann M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC21749/
https://ncbi.nlm.nih.gov/pubmed/9751774
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