Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-X(L)

How Bcl-2 and its pro-survival relatives prevent activation of the caspases that mediate apoptosis is unknown, but they appear to act through the caspase activator apoptosis protease–activating factor 1 (Apaf-1). According to the apoptosome model, the Bcl-2–like proteins preclude Apaf-1 activity by...

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Main Authors: Hausmann, George, O'Reilly, Lorraine A., van Driel, Rosemary, Beaumont, Jennifer G., Strasser, Andreas, Adams, Jerry M., Huang, David C.S.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2000
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174854/
https://ncbi.nlm.nih.gov/pubmed/10791976
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