The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain

Controlling neuropathic pain is an unmet medical need and we set out to identify new therapeutic candidates. AV411 (ibudilast) is a relatively nonselective phosphodiesterase inhibitor that also suppresses glial-cell activation and can partition into the CNS. Recent data strongly implicate activated...

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Détails bibliographiques
Auteurs principaux: LEDEBOER, ANNEMARIE, LIU, TONGYAO, SHUMILLA, JENNIFER A., MAHONEY, JOHN H., VIJAY, SHARMILA, GROSS, MATTHEW I., VARGAS, JOSEPH A., SULTZBAUGH, LANCE, CLAYPOOL, MARK D., SANFTNER, LAURA M., WATKINS, LINDA R., JOHNSON, KIRK W.
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174834/
https://ncbi.nlm.nih.gov/pubmed/18176632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1740925X0700035X
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