The Role of Intraorganellar Ca(2+)In Late Endosome–Lysosome Heterotypic Fusion and in the Reformation of Lysosomes from Hybrid Organelles

We have investigated the requirement for Ca(2+) in the fusion and content mixing of rat hepatocyte late endosomes and lysosomes in a cell-free system. Fusion to form hybrid organelles was inhibited by 1,2-bis(2-aminophenoxy) ethane-N,N,N′,N′-tetraacetic acid (BAPTA), but not by EGTA, and this inhibi...

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Hauptverfasser: Pryor, Paul R., Mullock, Barbara M., Bright, Nicholas A., Gray, Sally R., Luzio, J. Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2000
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174832/
https://ncbi.nlm.nih.gov/pubmed/10831609
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