Downregulation of 14-3-3σ Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes

In human epidermal keratinocytes, replicative senescence, is determined by a progressive decline of clonogenic and dividing cells. Its timing is controlled by clonal evolution, that is, by the continuous transition from stem cells to transient amplifying cells. We now report that downregulation of 1...

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Библиографические подробности
Главные авторы: Dellambra, Elena, Golisano, Osvaldo, Bondanza, Sergio, Siviero, Emanuela, Lacal, Pedro, Molinari, Marta, D'Atri, Stefania, De Luca, Michele
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2000
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174818/
https://ncbi.nlm.nih.gov/pubmed/10831615
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