Differential Regulation of P27(Kip1) Expression by Mitogenic and Hypertrophic Factors: Involvement of Transcriptional and Posttranscriptional Mechanisms

Platelet-derived growth factor-BB (PDGF-BB) acts as a full mitogen for cultured aortic smooth muscle cells (SMC), promoting DNA synthesis and cell proliferation. In contrast, angiotensin II (Ang II) induces cellular hypertrophy as a result of increased protein synthesis, but is unable to drive cells...

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Bibliographic Details
Main Authors: Servant, Marc J., Coulombe, Philippe, Turgeon, Benjamin, Meloche, Sylvain
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2000
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174813/
https://ncbi.nlm.nih.gov/pubmed/10662779
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