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Cdc42 and Rac Stimulate Exocytosis of Secretory Granules by Activating the Ip(3)/Calcium Pathway in Rbl-2h3 Mast Cells

We have expressed dominant-active and dominant-negative forms of the Rho GTPases, Cdc42 and Rac, using vaccinia virus to evaluate the effects of these mutants on the signaling pathway leading to the degranulation of secretory granules in RBL-2H3 cells. Dominant-active Cdc42 and Rac enhance antigen-s...

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Detalhes bibliográficos
Main Authors: Hong-Geller, Elizabeth, Cerione, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174803/
https://ncbi.nlm.nih.gov/pubmed/10662774
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