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Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42

Rho GTPases are key regulators of the actin cytoskeleton in membrane trafficking events. We previously reported that Cdc42 facilitates exocytosis in neuroendocrine cells by stimulating actin assembly at docking sites for secretory granules. These findings raise the question of the mechanism activati...

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Detalhes bibliográficos
Main Authors: Malacombe, Magali, Ceridono, Mara, Calco, Valérie, Chasserot-Golaz, Sylvette, McPherson, Peter S, Bader, Marie-France, Gasman, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538555/
https://ncbi.nlm.nih.gov/pubmed/16874303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601247
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