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Genetic identification of a novel NeuroD1 function in the early differentiation of islet α, PP and ε cells
Nkx2.2 and NeuroD1 are vital for proper differentiation of pancreatic islet cell types. Nkx2.2-null mice fail to form β cells, have reduced numbers of α and PP cells, and display an increase in ghrelin-producing ε cells. NeuroD1-null mice display a reduction of α and β cells after embryonic day (e)...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2174610/ https://ncbi.nlm.nih.gov/pubmed/17988662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.09.057 |
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