NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma

Tumor cells are characterized by unlimited proliferation and perturbed differentiation. Using single-cell RNA sequencing, we demonstrate that tumor cells in medulloblastoma (MB) retain their capacity to differentiate in a similar way as their normal originating cells, cerebellar granule neuron precu...

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Published in:Cell Rep
Main Authors: Cheng, Yan, Liao, Shengyou, Xu, Gang, Hu, Jian, Guo, Duancheng, Du, Fang, Contreras, Alejandra, Cai, Kathy Q., Peri, Suraj, Wang, Yuan, Corney, David C., Noronha, Anne Marie, Chau, Lianne Q., Zhou, Ginger, Wiest, David L., Bellacosa, Alfonso, Wechsler-Reya, Robert J., Zhao, Yi, Yang, Zeng-jie
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357167/
https://ncbi.nlm.nih.gov/pubmed/32579914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107782
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