Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons

Mutations of presenilin 1 (PS1) causing Alzheimer's disease selectively increase the secretion of the amyloidogenic βA4(1-42), whereas knocking out the gene results in decreased production of both βA4(1-40) and (1-42) amyloid peptides (De Strooper et al. 1998). Therefore, PS1 function is closel...

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Main Authors: Annaert, Wim G., Levesque, Lyne, Craessaerts, Kathleen, Dierinck, Inge, Snellings, Greet, Westaway, David, George-Hyslop, Peter St., Cordell, Barbara, Fraser, Paul, De Strooper, Bart
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1999
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174229/
https://ncbi.nlm.nih.gov/pubmed/10525535
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