Endoplasmic Reticulum (ER) Mannosidase I Is Compartmentalized and Required for N-Glycan Trimming to Man(5–6)GlcNAc(2) in Glycoprotein ER-associated Degradation

We had previously shown that endoplasmic reticulum (ER)-associated degradation (ERAD) of glycoproteins in mammalian cells involves trimming of three to four mannose residues from the N-linked oligosaccharide Man(9)GlcNAc(2). A possible candidate for this activity, ER mannosidase I (ERManI), accelera...

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Hlavní autoři: Avezov, Edward, Frenkel, Zehavit, Ehrlich, Marcelo, Herscovics, Annette, Lederkremer, Gerardo Z.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174174/
https://ncbi.nlm.nih.gov/pubmed/18003979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-05-0505
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