Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation

Chronic oxidative stress may play a critical role in the pathogenesis of many human cancers. Here, we report that mouse embryonic stem (ES) cells deficient in DNA mismatch repair responded abnormally when exposed to low levels of ionizing radiation, a stress known to generate oxidative DNA damage. E...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	DeWeese, Theodore L., Shipman, Jennifer M., Larrier, Nicole A., Buckley, Nicola M., Kidd, LaCreis R., Groopman, John D., Cutler, Richard G., te Riele, Hein, Nelson, William G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21740/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751765/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11915
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