Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation

Chronic oxidative stress may play a critical role in the pathogenesis of many human cancers. Here, we report that mouse embryonic stem (ES) cells deficient in DNA mismatch repair responded abnormally when exposed to low levels of ionizing radiation, a stress known to generate oxidative DNA damage. E...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	DeWeese, Theodore L., Shipman, Jennifer M., Larrier, Nicole A., Buckley, Nicola M., Kidd, LaCreis R., Groopman, John D., Cutler, Richard G., te Riele, Hein, Nelson, William G.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1998
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21740/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751765/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11915
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