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Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes

Phospholipase D (PLD) generates lipid signals that coordinate membrane trafficking with cellular signaling. PLD activity in vitro and in vivo is dependent on phosphoinositides with a vicinal 4,5-phosphate pair. Yeast and mammalian PLDs contain an NH(2)-terminal pleckstrin homology (PH) domain that h...

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Main Authors: Sciorra, Vicki A., Rudge, Simon A., Wang, Jiyao, McLaughlin, Stuart, Engebrecht, JoAnne, Morris, Andrew J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2002
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173982/
https://ncbi.nlm.nih.gov/pubmed/12486109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200205056
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