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The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling

CD148 is a receptor-like protein tyrosine phosphatase up-regulated on T cells after T cell receptor (TCR) stimulation. To examine the physiologic role of CD148 in TCR signaling, we used an inducible CD148-expressing Jurkat T cell clone. Expression of CD148 inhibits NFAT (nuclear factor of activated...

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Hlavní autoři: Lin, Joseph, Weiss, Arthur
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173795/
https://ncbi.nlm.nih.gov/pubmed/12913111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200303040
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