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Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma

The retinoblastoma (Rb) tumor suppressor controls cellular proliferation, survival, and differentiation and is functionally inactivated by mutations or hyperphosphorylation in most human cancers. Although activation of endogenous Rb is thought to provide an effective approach to suppress cell prolif...

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Detalhes bibliográficos
Main Authors: Jiang, Zhe, Zacksenhaus, Eldad
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173568/
https://ncbi.nlm.nih.gov/pubmed/11777937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200106084
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