APP processing is regulated by cytoplasmic phosphorylation

Amyloid-β peptide (Aβ) aggregate in senile plaque is a key characteristic of Alzheimer's disease (AD). Here, we show that phosphorylation of amyloid precursor protein (APP) on threonine 668 (P-APP) may play a role in APP metabolism. In AD brains, P-APP accumulates in large vesicular structures...

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Hlavní autoři: Lee, Ming-Sum, Kao, Shih-Chu, Lemere, Cynthia A., Xia, Weiming, Tseng, Huang-Chun, Zhou, Ying, Neve, Rachael, Ahlijanian, Michael K., Tsai, Li-Huei
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2003
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173445/
https://ncbi.nlm.nih.gov/pubmed/14557249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200301115
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