Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities

Diverse stimuli initiate the activation of apoptotic signaling pathways that often causes nuclear DNA fragmentation. Here, we report a new antiapoptotic protein, a caspase-activated DNase (CAD) inhibitor that interacts with ASK1 (CIIA). CIIA, by binding to apoptosis signal-regulating kinase 1 (ASK1)...

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Main Authors: Cho, Ssang-Goo, Kim, Jin Woo, Lee, Yong Hee, Hwang, Hyun Sub, Kim, Mi-Sung, Ryoo, Kanghyun, Kim, Myung Jin, Noh, Kyung Tae, Kim, Eun Kyung, Cho, Jun-Ho, Yoon, Kyoung Wan, Cho, Eun-Gyung, Park, Hee-Sae, Chi, Sung Wook, Lee, Min-Jae, Kang, Sang Sun, Ichijo, Hidenori, Choi, Eui-Ju
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173438/
https://ncbi.nlm.nih.gov/pubmed/14557248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200303003
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