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LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics
The small GTPase RhoA controls activity of serum response factor (SRF) by inducing changes in actin dynamics. We show that in PC12 cells, activation of SRF after serum stimulation is RhoA dependent, requiring both actin polymerization and the Rho kinase (ROCK)–LIM kinase (LIMK)–cofilin signaling pat...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173419/ https://ncbi.nlm.nih.gov/pubmed/12034774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200203126 |
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