ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

The small GTPase Rho acts on two effectors, ROCK and mDia1, and induces stress fibers and focal adhesions. However, how ROCK and mDia1 individually regulate signals and dynamics of these structures remains unknown. We stimulated serum-starved Swiss 3T3 fibroblasts with LPA and compared the effects o...

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Main Authors: Tsuji, Takahiro, Ishizaki, Toshimasa, Okamoto, Muneo, Higashida, Chiharu, Kimura, Kazuhiro, Furuyashiki, Tomoyuki, Arakawa, Yoshiki, Birge, Raymond B., Nakamoto, Tetsuya, Hirai, Hisamaru, Narumiya, Shuh
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2002
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173402/
https://ncbi.nlm.nih.gov/pubmed/12021256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200112107
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