Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis

Aberrant activation of the Wnt/β-catenin signaling pathway is associated with numerous human cancers and often correlates with the overexpression or amplification of the c-myc oncogene. Paradoxical to the cellular transformation potential of c-Myc is its ability to also induce apoptosis. Using an in...

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Autori principali: You, Zongbing, Saims, Daniel, Chen, Shaoqiong, Zhang, Zhaocheng, Guttridge, Denis C., Guan, Kun-liang, MacDougald, Ormond A., Brown, Anthony M.C., Evan, Gerard, Kitajewski, Jan, Wang, Cun-Yu
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173296/
https://ncbi.nlm.nih.gov/pubmed/11980918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200201110
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