Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins

We utilize structurally targeted peptides to identify a “t(C) fusion switch” inherent to the coil domains of the neuronal t-SNARE that pairs with the cognate v-SNARE. The t(C) fusion switch is located in the membrane-proximal portion of the t-SNARE and controls the rate at which the helical bundle t...

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Main Authors: Melia, Thomas J., Weber, Thomas, McNew, James A., Fisher, Lillian E., Johnston, Robert J., Parlati, Frank, Mahal, Lara K., Söllner, Thomas H., Rothman, James E.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173141/
https://ncbi.nlm.nih.gov/pubmed/12213837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200112081
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