Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

Autotaxin (ATX) is a tumor cell motility–stimulating factor, originally isolated from melanoma cell supernatants. ATX had been proposed to mediate its effects through 5′-nucleotide pyrophosphatase and phosphodiesterase activities. However, the ATX substrate mediating the increase in cellular motilit...

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Hauptverfasser: Umezu-Goto, Makiko, Kishi, Yasuhiro, Taira, Akitsu, Hama, Kotaro, Dohmae, Naoshi, Takio, Koji, Yamori, Takao, Mills, Gordon B., Inoue, Keizo, Aoki, Junken, Arai, Hiroyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2002
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173129/
https://ncbi.nlm.nih.gov/pubmed/12119361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200204026
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