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Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity

p21(Cip1/WAF1) has cell cycle inhibitory activity by binding to and inhibiting both cyclin/Cdk kinases and proliferating cell nuclear antigen. Here we show that p21(Cip1/WAF1) is induced in the cytoplasm during the course of differentiation of chick retinal precursor cells and N1E-115 cells. Ectopic...

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Detalhes bibliográficos
Main Authors: Tanaka, Hiroyuki, Yamashita, Toshihide, Asada, Minoru, Mizutani, Shuki, Yoshikawa, Hideki, Tohyama, Masaya
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173114/
https://ncbi.nlm.nih.gov/pubmed/12119358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200202071
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