Rapid exchange of mammalian topoisomerase IIα at kinetochores and chromosome arms in mitosis

Astable cell line (GT2-LPk) derived from LLC-Pk was created in which endogenous DNA topoisomerase IIα (topoIIα) protein was downregulated and replaced by the expression of topoIIα fused with enhanced green fluorescent protein (EGFP–topoIIα). The EGFP–topoIIα faithfully mimicked the distribution of t...

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Autori principali: Tavormina, Penny A., Côme, Marie-George, Hudson, Joanna R., Mo, Yin-Yuan, Beck, William T., Gorbsky, Gary J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2002
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Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173008/
https://ncbi.nlm.nih.gov/pubmed/12105179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200202053
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