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Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin

Loss of E-cadherin expression or function in tumors leads to a more invasive phenotype. In this study, we investigated whether the invasion suppressor activity of E-cadherin is mediated directly by tighter physical cell adhesion, indirectly by sequestering β-catenin and thus antagonizing β-catenin/T...

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Autori principali: Wong, Alice S.T., Gumbiner, Barry M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173007/
https://ncbi.nlm.nih.gov/pubmed/12810698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200212033
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