Intact satellite cells lead to remarkable protection against Smn gene defect in differentiated skeletal muscle

Deletion of murine Smn exon 7, the most frequent mutation found in spinal muscular atrophy, has been directed to either both satellite cells, the muscle progenitor cells and fused myotubes, or fused myotubes only. When satellite cells were mutated, mutant mice develop severe myopathic process, progr...

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Hlavní autoři: Nicole, Sophie, Desforges, Benedicte, Millet, Gaelle, Lesbordes, Jeanne, Cifuentes-Diaz, Carmen, Vertes, Dora, Cao, My Linh, De Backer, Fabienne, Languille, Laetitia, Roblot, Natacha, Joshi, Vandana, Gillis, Jean-Marie, Melki, Judith
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172949/
https://ncbi.nlm.nih.gov/pubmed/12743106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200210117
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