Androgen-stimulated DNA synthesis and cytoskeletal changes in fibroblasts by a nontranscriptional receptor action

In NIH3T3 cells, 0.001 nM of the synthetic androgen R1881 induces and stimulates association of androgen receptor (AR) with Src and phosphatidylinositol 3-kinase (Pl3-kinase), respectively, thereby triggering S-phase entry. 10 nM R1881 stimulates Rac activity and membrane ruffling in the absence of...

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Bibliographische Detailangaben
Hauptverfasser: Castoria, Gabriella, Lombardi, Maria, Barone, Maria Vittoria, Bilancio, Antonio, Di Domenico, Marina, Bottero, Daniela, Vitale, Flavia, Migliaccio, Antimo, Auricchio, Ferdinando
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172930/
https://ncbi.nlm.nih.gov/pubmed/12743104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200211099
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