Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers

Myelination results in a highly segregated distribution of axonal membrane proteins at nodes of Ranvier. Here, we show the role in this process of TAG-1, a glycosyl-phosphatidyl-inositol–anchored cell adhesion molecule. In the absence of TAG-1, axonal Caspr2 did not accumulate at juxtaparanodes, and...

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Auteurs principaux: Traka, Maria, Goutebroze, Laurence, Denisenko, Natalia, Bessa, Maria, Nifli, Artemisia, Havaki, Sophia, Iwakura, Yoichiro, Fukamauchi, Fumihiko, Watanabe, Kazutada, Soliven, Betty, Girault, Jean-Antoine, Karagogeos, Domna
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2003
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172849/
https://ncbi.nlm.nih.gov/pubmed/12975355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200305078
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