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Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing β-catenin in many biological systems. We have uncovered a new noncanonical pathway through which Wnt-5a antagonizes...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172823/ https://ncbi.nlm.nih.gov/pubmed/12952940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200303158 |
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