Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs

The signaling enzyme phospholipase D1 (PLD1) facilitates membrane vesicle trafficking. Here, we explore how PLD1 subcellular localization is regulated via Phox homology (PX) and pleckstrin homology (PH) domains and a PI4,5P(2)-binding site critical for its activation. PLD1 localized to perinuclear e...

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Bibliographische Detailangaben
Hauptverfasser: Du, Guangwei, Altshuller, Yelena M., Vitale, Nicolas, Huang, Ping, Chasserot-Golaz, Sylvette, Morris, Andrew J., Bader, Marie-France, Frohman, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172799/
https://ncbi.nlm.nih.gov/pubmed/12876278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200302033
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