Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs

The signaling enzyme phospholipase D1 (PLD1) facilitates membrane vesicle trafficking. Here, we explore how PLD1 subcellular localization is regulated via Phox homology (PX) and pleckstrin homology (PH) domains and a PI4,5P(2)-binding site critical for its activation. PLD1 localized to perinuclear e...

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Détails bibliographiques
Auteurs principaux: Du, Guangwei, Altshuller, Yelena M., Vitale, Nicolas, Huang, Ping, Chasserot-Golaz, Sylvette, Morris, Andrew J., Bader, Marie-France, Frohman, Michael A.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2003
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172799/
https://ncbi.nlm.nih.gov/pubmed/12876278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200302033
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