Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs

The signaling enzyme phospholipase D1 (PLD1) facilitates membrane vesicle trafficking. Here, we explore how PLD1 subcellular localization is regulated via Phox homology (PX) and pleckstrin homology (PH) domains and a PI4,5P(2)-binding site critical for its activation. PLD1 localized to perinuclear e...

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Autors principals: Du, Guangwei, Altshuller, Yelena M., Vitale, Nicolas, Huang, Ping, Chasserot-Golaz, Sylvette, Morris, Andrew J., Bader, Marie-France, Frohman, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2003
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172799/
https://ncbi.nlm.nih.gov/pubmed/12876278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200302033
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