Calcium-regulated exocytosis of dense-core vesicles requires the activation of ADP-ribosylation factor (ARF)6 by ARF nucleotide binding site opener at the plasma membrane

The ADP ribosylation factor (ARF) GTP binding proteins are believed to mediate cytoskeletal remodeling and vesicular trafficking along the secretory pathway. Here we show that ARF6 is specifically associated with dense-core secretory granules in neuroendocrine PC12 cells. Stimulation with a secretag...

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Bibliographic Details
Main Authors: Vitale, Nicolas, Chasserot-Golaz, Sylvette, Bailly, Yannick, Morinaga, Naoko, Frohman, Michael A., Bader, Marie-France
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173505/
https://ncbi.nlm.nih.gov/pubmed/12379803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200203027
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