Cellular stresses induce the nuclear accumulation of importin α and cause a conventional nuclear import block

We report here that importin α accumulates reversibly in the nucleus in response to cellular stresses including UV irradiation, oxidative stress, and heat shock. The nuclear accumulation of importin α appears to be triggered by a collapse in the Ran gradient, resulting in the suppression of the nucl...

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Bibliografiske detaljer
Main Authors: Miyamoto, Yoichi, Saiwaki, Takuya, Yamashita, Junichi, Yasuda, Yoshinari, Kotera, Ippei, Shibata, Satoshi, Shigeta, Masaki, Hiraoka, Yasushi, Haraguchi, Tokuko, Yoneda, Yoshihiro
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2004
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172376/
https://ncbi.nlm.nih.gov/pubmed/15184398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200312008
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