Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by β(1) integrins

We show here that β(1) integrins selectively modulate insulin-like growth factor type I receptor (IGF-IR) signaling in response to IGF stimulation. The β(1A) integrin forms a complex with the IGF-IR and insulin receptor substrate-1 (IRS-1); this complex does not promote IGF-I mediated cell adhesion...

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Hlavní autoři: Goel, Hira Lal, Fornaro, Mara, Moro, Loredana, Teider, Natalia, Rhim, Johng S., King, Michael, Languino, Lucia R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2004
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172270/
https://ncbi.nlm.nih.gov/pubmed/15289498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200403003
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