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Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility
Cells lacking vinculin are highly metastatic and motile. The reasons for this finding have remained unclear. Both enhanced survival and motility are critical to metastasis. Here, we show that vinculin null (vin(−/−)) cells and cells expressing a vinculin Y822F mutant have increased survival due to u...
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| Главные авторы: | , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172187/ https://ncbi.nlm.nih.gov/pubmed/15138291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200308011 |
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